.png)
Roundup, the world’s most widely used herbicide, has been linked to serious health risks, including cancer, due to its active ingredient, glyphosate, and newer formulations containing chemicals like diquat. With over 170,000 lawsuits filed against Bayer, Roundup’s manufacturer, many are asking: How does Roundup cause cancer? This article dives into the scientific mechanisms, key studies, related cancers, and steps you can take to protect yourself. Whether you’re a farmer, gardener, or concerned consumer, understanding these risks is crucial.
Glyphosate, Roundup’s primary ingredient until recent reformulations, is classified by the World Health Organization’s International Agency for Research on Cancer (IARC) as a “probable human carcinogen” (2015). Below, we explore the biological mechanisms by which Roundup may cause cancer, based on peer-reviewed studies.
Glyphosate can damage DNA, a critical step in cancer development. Studies, such as a 2023 review in Environmental Research, show that glyphosate induces DNA strand breaks and chromosomal damage in human and animal cells. This damage can lead to mutations that trigger uncontrolled cell growth, a hallmark of cancer.
Roundup exposure generates reactive oxygen species (ROS), leading to oxidative stress, which damages cells and promotes cancer.
Glyphosate may act as an endocrine disruptor, interfering with hormone signaling pathways that regulate cell growth.
Glyphosate disrupts the gut microbiome, which may indirectly promote cancer by weakening immune function.
While non-Hodgkin lymphoma (NHL) is the most well-documented cancer associated with Roundup, other cancers have been reported in lawsuits and studies:
In 2023, Bayer began replacing glyphosate-based Roundup for residential use with formulations containing diquat, fluazifop-P-butyl, and other chemicals. A 2024 Friends of the Earth analysis found these formulations to be up to 45 times more toxic than glyphosate, with diquat linked to kidney, liver, and reproductive harm. These chemicals may also contribute to cancer through similar mechanisms (e.g., oxidative stress), but research is ongoing.
The debate over Roundup’s safety centers on conflicting findings:
Critics argue that the EPA relies on biased studies, while Bayer faces pressure from over 58,000 ongoing lawsuits as of 2025, with recent verdicts awarding up to $2.25 billion.
Is Roundup still safe to use?
The EPA says glyphosate is safe when used as directed, but the IARC and independent studies link it to cancer. New formulations may pose greater risks.
What cancers are linked to Roundup?
Non-Hodgkin lymphoma is the primary cancer, with emerging links to multiple myeloma, leukemia, and others.
Can I file a lawsuit if I used Roundup and got cancer?
Yes, if you have a qualifying cancer and evidence of Roundup exposure. Consult an attorney to evaluate your case.
Are new Roundup formulations safer?
No, 2024 studies suggest they are more toxic than glyphosate, with risks to human health and the environment.
How can I prove Roundup caused my cancer?
Medical records, exposure evidence (e.g., receipts, employment records), and expert testimony are key. An attorney can guide you.
If you or a loved one developed cancer after using Roundup, you may be eligible for compensation. The science linking Roundup to cancer is compelling, and legal action can hold Bayer accountable. Contact Clinton O. Middleton, Attorney at Law, at (703) 777-9630 or fill out our online form for a free case review to explore your options.
